How to Avoid Carbon Monoxide Poisoning

As People Head Indoors, the Risk for CO Intoxication Increases

© Stephen Allen Christensen

Nov 20, 2008
Gas-fueled Lantern, Steve Christensen
Carbon monoxide remains a leading cause of fatal poisoning. Understanding the causes, risks, and prevention of CO intoxication will decrease mortality and morbidity.

Carbon monoxide (CO) is the product of incomplete combustion of carbon-based substances, such as fossil fuels. Carbon monoxide is an odorless, colorless, tasteless, non-irritating, toxic gas.

CO is the leading cause of poisoning deaths in the United States and other industrial countries. (Kao LW. Toxicity associated with carbon monoxide. Clin Lab Med. 2006; 26(1): 99-125 and Omaye S. Metabolic modulation of carbon monoxide toxicity. Toxicology 2002;180(2):139-50)

Since CO is undetectable to humans, unwitting exposures can lead to significant intoxication and death. Lethal poisoning can occur within ten minutes in a closed garage where a car is running.

Where is Carbon Monoxide Found?

CO is produced in any situation where organic material is burned in a limited-oxygen environment. A partial list includes:

  • Appliances (including water heaters) that burn coal, gasoline, natural gas, oil, propane, or wood
  • Automobile engines
  • Industrial settings
  • Indoor or portable heaters
  • Camp stoves or lanterns
  • Charcoal grills
  • Wood stoves
  • Methylene chloride fumes (from paint strippers) are metabolized in the body to CO and can cause severe intoxication

What are the Signs and Symptoms of Carbon Monoxide Poisoning?

The signs and symptoms of CO poisoning stem from its displacement of oxygen from hemoglobin in the red blood cells. CO binds to hemoglobin much more tightly than oxygen does; tissues and organs are thus deprived of critically-needed oxygen.

Non-specific flu-like symptoms are typical of CO intoxication:

  • Headache
  • Nausea and vomiting
  • Weakness
  • Drowsiness
  • Dizziness
  • Abdominal pain
  • Sore throat
  • Dry cough

More severe intoxication can result in:

  • Rapid or irregular heartbeat
  • Hyperventilation and difficulty breathing
  • Confusion
  • Seizures
  • Collapse
  • Coma
  • Death

Unlike flu, CO poisoning does not cause high fever. The classic cherry-red coloration of the skin that is associated with CO poisoning is RARE and is not a reliable diagnostic sign. Sometimes, chronic exposure to low levels of CO can lead to confusion, memory loss, and loss of coordination.

Diagnosis of CO poisoning is often missed unless exposure is suspected. Occasionally, symptoms like confusion, memory loss, or loss of coordination may not appear for days or even months following initial exposure.

What is the Treatment for Carbon Monoxide Poisoning?

First, individuals who have been exposed to CO must be moved to fresh air. Basic life support (if needed) and oxygen must be administered. Since CO is difficult to clear from tissues, and since tissue damage may continue for many hours after poisoning occurs, it is essential that anyone with known or suspected exposure be transported to a hospital for further evaluation.

The initial medical treatment for CO poisoning includes 100% oxygen and medications to correct metabolic abnormalities. Patients may be transported to facilities where hyperbaric oxygen can be administered.

Victims of mild CO poisoning typically recover, but up to 50% of those who survive moderate to severe intoxication experience long-term complications (e.g., brain or heart damage).

How can Carbon Monoxide Poisoning be Prevented?

  1. Watch for symptoms among family members or co-workers (symptoms may resolve with a change in location, only to recur upon returning to the area where exposure occurs)
  2. Never run automobiles, motorcycles, lawn mowers, or snow blowers in a closed space
  3. Never burn charcoal indoors
  4. Have gas-burning appliances and heating systems inspected annually
  5. Inspect flues and chimneys at least annually
  6. Never go to sleep in an area where a portable gas- or propane-burning heater or lantern is in use
  7. Use paint strippers only in well-ventilated areas
  8. Install CO alarms (available in stores) in areas of potential risk

Winter brings people indoors, where they burn fuels to stay warm. A few simple precautions can avert tragedy as the season unfolds.


The copyright of the article How to Avoid Carbon Monoxide Poisoning in General Medicine is owned by Stephen Allen Christensen. Permission to republish How to Avoid Carbon Monoxide Poisoning in print or online must be granted by the author in writing.


Gas-fueled Lantern, Steve Christensen
       


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Comments
Dec 3, 2008 8:17 AM
Guest :
wow
Mar 24, 2009 12:10 PM
Guest :
Can exposure to CO cause an autoimmune disease like AS
Mar 25, 2009 7:28 AM
Stephen Allen Christensen :
You've touched on a topic that prompts some discussion. I'll try to be brief.
Back in 2004, researchers who were trying to explain why CO poisoning caused delayed brain damage discovered that it was likely due to an autoimmune response. When the initial poisoning event injured myelin basic protein (MBP) in brain tissue, lymphocytes poured in to remove the altered protein. That's a normal immune response. Unfortunately, the lymphocytes didn't know when to stop cleaning, so they attacked normal MBP as well. The changes in MBP that resulted from CO poisoning looked a lot like those that occur in MS. Stephen Thom, MD, at the University of Pennsylvania School of Medicine, was the chief investigator in that study.
Well, nothing ever seems cut-and-dried in medicine: Another study in 2007 showed that exposure to exogenous CO actually decreased the inflammatory damage of experimentally-induced autoimmune encephalomyelitis. Therefore, the researchers in this study (Chora, et al, Journal of Clinical Investigation, 2007) suggested that exposure to CO might be useful for treating certain autoimmune conditions, specifically the neuroinflammation found in MS.
While these studies seem contradictory at first glance, they may just serve to emphasize that too much of a "good thing" can be harmful.
3 Comments